Role of kynurenine in promoting the generation of exhausted CD8 < sup > + < /sup > T cells in colorectal cancer

In conclusion, our study revealed a novel mechanism underlying the metabolic factors found in tumor microenvironment which could induce CD8+ T cells exhaustion. Our findings provided a new strategy of restoring the antitumor activity of CD8+ T cells through combined targeting of the IDO1/Kyn and PD-1/PD-L1 pathways in patients with CRC.PMID:33841677 | PMC:PMC8014392
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research