Collagen IV differentially regulates planarian stem cell potency and lineage progression [Developmental Biology]

The extracellular matrix (ECM) provides a precise physical and molecular environment for cell maintenance, self-renewal, and differentiation in the stem cell niche. However, the nature and organization of the ECM niche is not well understood. The adult freshwater planarian Schmidtea mediterranea maintains a large population of multipotent stem cells (neoblasts),...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Developmental Biology Biological Sciences Source Type: research