Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells [Immunology and Inflammation]

The transcription factor IRF4 is required for CD8+ T cell activation, proliferation, and differentiation to effector cells and thus is essential for robust CD8+ T cell responses. The function of IRF4 in memory CD8+ T cells yet needs to be explored. To investigate the role of IRF4 for maintaining differentiation...

Source: Proceedings of the National Academy of Sciences - April 15, 2021 Category: Science Authors: Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch–Nolte, Hans–Willi Mittrucker, Friederike Raczkowski Tags: Immunology and Inflammation Biological Sciences Source Type: research