Stereotactic cisternal lavage in patients with aneurysmal subarachnoid hemorrhage with urokinase and nimodipine for the prevention of secondary brain injury (SPLASH): study protocol for a randomized controlled trial

DiscussionNew approaches for the prevention and therapy of secondary brain injury in patients with aSAH are urgently needed. We propose this RCT to assess the clinical safety and efficacy of a novel therapy protocol for intrathecal administration of urokinase, nimodipine, and Ringer ’s solution.Trial registrationDeutsches Register Klinischer Studien (German Clinical Trials Register),DRKS00015645. Registered on 8 May 2019
Source: Trials - Category: Research Source Type: clinical trials