Cancers, Vol. 13, Pages 1889: A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam
Cancers, Vol. 13, Pages 1889: A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam
Cancers doi: 10.3390/cancers13081889
Authors:
Arthur Bongrand
Charbel Koumeir
Daphnée Villoing
Arnaud Guertin
Ferid Haddad
Vincent Métivier
Freddy Poirier
Vincent Potiron
Noël Servagent
Stéphane Supiot
Grégory Delpon
Sophie Chiavassa
Proton therapy (PRT) is an irradiation technique that aims at limiting normal tissue damage while maintaining the tumor response. To study its specificities, the ARRONAX cyclotron is currently developing a preclinical structure compatible with biological experiments. A prerequisite is to identify and control uncertainties on the ARRONAX beamline, which can lead to significant biases in the observed biological results and dose–response relationships, as for any facility. This paper summarizes and quantifies the impact of uncertainty on proton range, absorbed dose, and dose homogeneity in a preclinical context of cell or small animal irradiation on the Bragg curve, using Monte Carlo simulations. All possible sources of uncertainty were investigated and discussed independently. Those with a significant impact were identified, and protocols were established to reduce their consequences. Overall, the uncertainties evaluated were similar to those from clinical practice and are considered compatible with the performance of radiobiological experiments, as well as the study of dose–resp...
Source: Cancers - Category: Cancer & Oncology Authors: Arthur Bongrand Charbel Koumeir Daphn ée Villoing Arnaud Guertin Ferid Haddad Vincent M étivier Freddy Poirier Vincent Potiron No ël Servagent St éphane Supiot Gr égory Delpon Sophie Chiavassa Tags: Article Source Type: research