Cancers, Vol. 13, Pages 1893: Management of Synchronous Extrathoracic Oligometastatic Non-Small Cell Lung Cancer

Cancers, Vol. 13, Pages 1893: Management of Synchronous Extrathoracic Oligometastatic Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers13081893 Authors: Gregory D. Jones Harry B. Lengel Meier Hsu Kay See Tan Raul Caso Amanda Ghanie James G. Connolly Manjit S. Bains Valerie W. Rusch James Huang Bernard J. Park Daniel R. Gomez David R. Jones Gaetano Rocco Stage IV non-small cell lung cancer (NSCLC) accounts for 35 to 40% of newly diagnosed cases of NSCLC. The oligometastatic state—≤5 extrathoracic metastatic lesions in ≤3 organs—is present in ~25% of patients with stage IV disease and is associated with markedly improved outcomes. We retrospectively identified patients with extrathoracic oligometastatic NSCLC who underwent primary tumor resection at our institution from 2000 to 2018. Event-free survival (EFS) and overall survival (OS) were estimated using the Kaplan–Meier method. Factors associated with EFS and OS were determined using Cox regression. In total, 111 patients with oligometastatic NSCLC underwent primary tumor resection; 87 (78%) had a single metastatic lesion. Local consolidative therapy for metastases was performed in 93 patients (84%). Seventy-seven patients experienced recurrence or progression. The five-year EFS was 19% (95% confidence interval (CI), 12–29%), and the five-year OS was 36% (95% CI, 27–50%). Factors independently associated with EFS were primary tumor size (hazard ratio (HR), 1.15 (95% CI, 1....
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research