Metabolic Profile of Women with Premature Ovarian Insufficiency Compared with that of Age-Matched Healthy Controls

Premature ovarian insufficiency (POI) is an enigmatic gynecological, endocrine syndrome described as amenorrhea due to the loss of ovarian function under the age of 40 years [1-3], and is characterized by elevated levels of gonadotrophins and decreased levels of estradiol [4]. The incidence of POI has been estimated to be approximately 1% by the age of 40 [5], and 0.01% by the age of 20 [6]. The clinical presentation of POI is highly heterogeneous and can be associated with delayed puberty, primary amenorrhea, or secondary amenorrhea before the age of 40 [7].

Source: Maturitas - April 14, 2021 Category: Primary Care Authors: Yizhou Huang, Yifei Lv, Tongyun Qi, Zhou Luo, Xingjun Meng, Qian Ying, Die Li, Chunming Li, Yibing Lan, Ketan Chu, Dongxia Fu, Peiqiong Chen, Wenxian Xu, Yingxian Jia, Saisai Li, Xiaoping Cen, Li Li, Ling Xu, Linjuan Ma, Jianhong Zhou Source Type: research