The feasibility of circulating tumor DNA analysis as a marker of recurrence in triple-negative breast cancer

In conclusion, the present study evaluated a high-sensitivity detection system for frequently mutated genes that was also applicable for cell-free DNA. The PI3K/AKT pathway was revealed to be activated in patients harboring PIK3CA H1047R and AKT1 E17K mutations; therefore, the PI3K/AKT pathway may be a promising candidate for targeted therapy in these patients.PMID:33841581 | PMC:PMC8020385 | DOI:10.3892/ol.2021.12681

Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Satoshi Okazaki Takaaki Sasaki Shunsuke Yasuda Masahiro Abe Nana Yoshida Ryohei Yoshida Kei Ishibashi Yoshinori Minami Shunsuke Okumura Shinichi Chiba Hidehiro Takei Ryusuke Hayashi Toshihiro Nagato Hiroya Kobayashi Ayumu Sugitani Yusuke Ono Yusuke Mizuka Source Type: research