An insight into the promoter methylation of PHF20L1 and the gene association with metastasis in breast cancer

CONCLUSIONS: Our findings showed differences in methylation of PHF20L1 promoter region near TSS and upstream in BC subtypes; its overexpression impacted DMFS. We found that PHF20L1 is targeted by miR96-5p, miR9-5p and miR182-5p, which are involved in proliferation and metastasis, and regulates genes engaged in processes such as alternative splicing.PMID:33847474 | DOI:10.17219/acem/133426
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research