Metabolome and lipidome derangements during a severe mast cell activation event in a patient with indolent systemic mastocytosis

Capsule summary: Extensive mast cell activation leads to severe endothelial dysfunction with depletion of important amino acids in the nitric oxide signaling pathway and many lysophosphatidylcholine (LPC) variants with histamine possibly as the key driving force behind the severe clinical symptoms.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research