An antipathogenic compound that targets the OxyR peroxide sensor in < em > Pseudomonas aeruginosa < /em >

Conclusion. These results suggest that compound 1 could be an antipathogenic hit inhibiting the P. aeruginosa OxyR. More importantly, our study provides an insight into the computer-based discovery of new-paradigm selective antibacterials to treat Gram-negative bacterial infections presumably with few concerns of drug resistance.PMID:33830911 | DOI:10.1099/jmm.0.001341

Source: Journal of Medical Microbiology - April 8, 2021 Category: Microbiology Authors: Hyo-Young Oh Shivakumar S Jalde In-Young Chung Yeon-Ji Yoo Hye-Jeong Jang Hyun-Kyung Choi You-Hee Cho Source Type: research