Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents

Comp Med. 2021 Apr 8. doi: 10.30802/AALAS-CM-20-000107. Online ahead of print.ABSTRACTCorynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problemin preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment ofpatient-derived xenograft tumor models. The use of antimicrobial agents for C. bovis is controversial in light of reports of poor efficacy and the possibility of selection for resistant strains. The purpose of this study was to describe the antimicrobial susceptibilities of C. bovis isolates obtained exclusively from immunodeficient rodents in order to aid in antimicrobial dose determination. Between 1995 and 2018, 15 isolates were collected from 11 research institutions across the United States. Antimicrobial susceptibility testing was performed for 24 antimicrobials commonly used against gram-positive bacteria. Our results provide an updated understanding of the susceptibility profiles of rodent C. bovis isolates, indicating little variability between geographically and temporally distant isolates. These results will facilitate appropriate antimicrobial use to prevent and treat C. bovis infections in immunodeficient rodents.PMID:33836843 | DOI:10.30802/AALAS-CM-20-000107
Source: Comparative Medicine - Category: Zoology Authors: Source Type: research