Association of triglyceride-glucose index and lung health: a population-based study

Chest. 2021 Apr 8:S0012-3692(21)00673-5. doi: 10.1016/j.chest.2021.03.056. Online ahead of print.ABSTRACTBACKGROUND: Metabolic syndrome and insulin resistance are associated with worsened outcomes of chronic lung disease. The triglyceride-glucose index (TyG), a measure of metabolic dysfunction, is associated with metabolic syndrome and insulin resistance, but its relationship to lung health is unknown.RESEARCH QUESTION: What is the relationship of TyG to respiratory symptoms, chronic lung disease, and lung function?STUDY DESIGN: and Methods: We analyzed the National Health and Nutrition Examination Survey from 1999-2012. Participants included fasting adults age ≥40 years (n=6,893) with lung function measurements in a subset (n=3,383). Associations of TyG with respiratory symptoms (cough, phlegm production, wheeze, exertional dyspnea), chronic lung disease (diagnosed asthma, chronic bronchitis, emphysema), and lung function (FEV1, FVC, and obstructive or restrictive spirometry pattern) were evaluated adjusting for sociodemographic variables, comorbidities, and smoking. TyG was compared to insulin resistance, represented by the homeostatic model assessment of insulin resistance (HOMA-IR), and to metabolic syndrome.RESULTS: TyG was moderately correlated with HOMA-IR (ρ=0.51) and had good discrimination for metabolic syndrome (AUROC=0.80). A one-unit increase in TyG was associated with higher odds of cough (adjusted odds ratio [aOR] 1.28; 95% confidence interval [CI] 1.06-1.54...
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research