Adiposity and interstitial lung abnormalities in community dwelling adults: the MESA cohort study

Chest. 2021 Apr 9:S0012-3692(21)00675-9. doi: 10.1016/j.chest.2021.03.058. Online ahead of print.ABSTRACTBACKGROUND: Obesity is associated with restrictive ventilatory defects and faster rate of decline in forced vital capacity (FVC). This association is not exclusively mediated by mechanical factors and may reflect direct pulmonary injury by adipose-derived mediators.RESEARCH QUESTION: Is adipose tissue involved in the pathogenesis of interstitial lung disease (ILD)?STUDY DESIGN AND METHODS: We evaluated the association of CT measures of pericardial, abdominal visceral, and abdominal subcutaneous adipose tissue, with high attenuation areas (HAA) and interstitial lung abnormalities (ILA) in a large multi-center cohort study of community-dwelling adults, using multivariable-adjusted models. We secondarily evaluated the association of adipose depot size with FVC and biomarkers of obesity and inflammation.RESULTS: In fully adjusted models, every doubling in pericardial adipose tissue volume was associated with a 63.4-unit increase in HAA (95%CI 55.5-71.3), 20% increased odds of ILA (95%CI -2% to 50%), and a 5.5% decrease in percent-predicted FVC (95%CI -6.8% to -4.3%). Interleukin-6 levels accounted for 8% of the association between pericardial adipose tissue and HAA. Every doubling in visceral adipose tissue area was associated with a 41.5-unit increase in HAA (95%CI 28.3-54.7), 30% increased odds of ILA (95%CI -10% to 80%), and a 5.4% decrease in percent-predicted FVC (95%CI -...
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research