An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications [Medical Sciences]
We describe the development of OncoFAP, an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to human FAP with affinity in the subnanomolar concentration range and cross-reacts with the murine isoform of the protein. We generated various fluorescent and radiolabeled derivatives of OncoFAP...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Jacopo Millul, Gabriele Bassi, Jacqueline Mock, Abdullah Elsayed, Christian Pellegrino, Aureliano Zana, Sheila Dakhel Plaza, Lisa Nadal, Andreas Gloger, Eleonore Schmidt, Ilaria Biancofiore, Etienne J. Donckele, Florent Samain, Dario Neri, Samuele Cazzama Tags: Medical Sciences Biological Sciences Source Type: research