Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing [Physiology]

Myosin-based regulation in the heart muscle modulates the number of myosin motors available for interaction with calcium-regulated thin filaments, but the signaling pathways mediating the stronger contraction triggered by stretch between heartbeats or by phosphorylation of the myosin regulatory light chain (RLC) remain unclear. Here, we used RLC probes in...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Physiology Biological Sciences Source Type: research