A translational riboswitch coordinates nascent transcription-translation coupling [Biophysics and Computational Biology]

Bacterial messenger RNA (mRNA) synthesis by RNA polymerase (RNAP) and first-round translation by the ribosome are often coupled to regulate gene expression, yet how coupling is established and maintained is ill understood. Here, we develop biochemical and single-molecule fluorescence approaches to probe the dynamics of RNAP–ribosome interactions on an mRNA...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biophysics and Computational Biology Biological Sciences Source Type: research