Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma [Genetics]

Sex can be an important determinant of cancer phenotype, and exploring sex-biased tumor biology holds promise for identifying novel therapeutic targets and new approaches to cancer treatment. In an established isogenic murine model of glioblastoma (GBM), we discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer...

Source: Proceedings of the National Academy of Sciences - April 13, 2021 Category: Science Authors: Najla Kfoury, Zongtai Qi, Briana C. Prager, Michael N. Wilkinson, Lauren Broestl, Kristopher C. Berrett, Arnav Moudgil, Sumithra Sankararaman, Xuhua Chen, Jason Gertz, Jeremy N. Rich, Robi D. Mitra, Joshua B. Rubin Tags: Genetics Biological Sciences Source Type: research