DNA structure itself is involved in genome regulation

(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) When genes must be accessed for transcription, the DNA double helix unwinds and the strands separate from each other so that all the elements needed for gene expression can access. This process results in the accumulation of DNA supercoiling that needs to be resolved. A study published in Cell Reports reveals that DNA supercoiling is involved in regulating gene expression rather than just being collateral damage that must be fixed, as was previously believed.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news