To 1000  Gy and back again: a systematic review on dose-response evaluation in selective internal radiation therapy for primary and secondary liver cancer

CONCLUSION: Although the existing evidence demonstrates a dose-response relationship in SIRT for both primary liver tumours and liver metastases, many pieces of the puzzle are still missing, hampering the definition of standardized dose thresholds. Nonetheless, most current evidence points towards a target mean dose of 100-250 Gy for HCC and 40-60 Gy for CRC. The field would greatly benefit from a reporting standard and prospective studies designed to elucidate the dose-response relation in different tumour types.PMID:33839892 | DOI:10.1007/s00259-021-05340-0

Source: Molecular Medicine - April 11, 2021 Category: Molecular Biology Authors: Joey Roosen Nienke J M Klaassen Lovisa E L Westlund Gotby Christiaan G Overduin Marcel Verheij Mark W Konijnenberg J Frank W Nijsen Source Type: research