Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens

Trends Microbiol. 2021 Apr 6:S0966-842X(21)00066-4. doi: 10.1016/j.tim.2021.03.007. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.PMID:33836929 | DOI:10.1016/j.tim.2021.03.007
Source: Trends in Microbiology - Category: Microbiology Authors: Source Type: research
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