Effects of Sertraline on Spermatogenesis of Male Rats and its Reversibility after Terminating the Drug

Conclusion: Within the time-frame studied, Sertraline can induce transitory changes in serum FSH of male rats without concomitant spermatogenic changes within the testes. This hormonal change appears to be reversible following withholding of Sertraline. The long-term effect of Sertraline usage on hormonal status and spermatogenesis in rats needs further investigation.PMID:33813731 | DOI:10.22037/uj.v18i.6458

Source: Urology Journal - April 4, 2021 Category: Urology & Nephrology Authors: Hamidreza Ghorbani Alireza Akhavanrezayat Lida Jarahi Bahram Memar Sakineh Amouian Armin Attaranzadeh Sadegh Ebrahimi Source Type: research