Changes in Test Methods for Internationalization in the Japanese Pharmacopoeia (Part 1): Establishment of a Quantitative Test Method for Clonidine Hydrochloride Using HPLC Analysis

In this study, we synthesized impurities of clonidine hydrochloride and determined their purities using quantitative NMR. In addition, the complete separation conditions of these compounds by HPLC were examined, and simultaneous analysis was performed.PMID:33790124 | DOI:10.1248/yakushi.20-00237

Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 1, 2021 Category: Drugs & Pharmacology Authors: Aika Maniwa Genichiro Tsuji Takahito Ito Nahoko Uchiyama Junko Hosoe Takashi Ohtsuki Hiroshi Matsufuji Yosuke Demizu Yukihiro Goda Source Type: research