C5aR inhibition of non-immune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia

Crucially, we here show for the first time, that targeting anaphylotoxin receptors C3aR and C5aR in highly differentiated, 3D respiratory tissues can prevent intrinsic lung inflammation and tissue damage.

Source: Journal of Allergy and Clinical Immunology - April 11, 2021 Category: Allergy & Immunology Authors: Wilfried Posch, Jonathan Vosper, Asma Noureen, Viktoria Zaderer, Christina Witting, Giulia Bertacchi, Ronald Gstir, Przemyslaw A. Filipek, G ünther K. Bonn, Lukas A. Huber, Rosa Bellmann-Weiler, Cornelia Lass-Flörl, Doris Wilflingseder Source Type: research