Epigenetic regulations in mammalian spermatogenesis: RNA-m < sup > 6 < /sup > A modification and beyond

Cell Mol Life Sci. 2021 Apr 9. doi: 10.1007/s00018-021-03823-9. Online ahead of print.ABSTRACTEmerging evidence shows that m6A, one of the most abundant RNA modifications in mammals, is involved in the entire process of spermatogenesis, including mitosis, meiosis, and spermiogenesis. "Writers" catalyze m6A formation on stage-specific transcripts during male germline development, while "erasers" remove m6A modification to maintain a balance between methylation and demethylation. The different functions of RNA-m6A transcripts depend on their recognition by "readers". m6A modification mediates RNA metabolism, including mRNA splicing, translation, and degradation, as well as the maturity and biosynthesis of non-coding RNAs. Sperm RNA profiles are easily affected by environmental exposure and can even be inherited for several generations, similar to epigenetic inheritance. Here, we review and summarize the critical role of m6A in different developmental stages of male germ cells, to understand of the mechanisms and epigenetic regulation of m6A modifications. In addition, we also outline and discuss the important role of non-coding RNAs in spermatogenesis and RNA modifications in epigenetic inheritance.PMID:33835194 | DOI:10.1007/s00018-021-03823-9
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Source Type: research