Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases

This article primarily aims to develop a comprehensive and better understanding of Ibuprofen, its pharmacological features, therapeutic benefits, and possible but less understood medicinal properties apart from major challenges in its future application.KEY POINTSIbuprofen, an NSAID, is a classical anti-inflammatory therapeutic agent.Pro-apoptotic roles of NSAIDs have been explored in detail in the past, holding the key in anti-cancer therapies.Excessive and continuous use of NSAIDs may have several side effects and multiple organ damage.Hyperactivated Inflammation initiates multifold detrimental changes in multiple pathological conditions.Targeting inflammatory pathways hold the key to several therapeutic strategies against many diseases, including cancer, microbial infections, multiple sclerosis, and many other brain diseases.PMID:33820460 | DOI:10.1080/03602532.2021.1903488

Source: Drug Metabolism Reviews - April 6, 2021 Category: Drugs & Pharmacology Authors: Arun Upadhyay Ayeman Amanullah Vibhuti Joshi Rohan Dhiman Vijay Kumar Prajapati Krishna Mohan Poluri Amit Mishra Source Type: research