Treatment for bleeding oesophageal varices in people with decompensated liver cirrhosis: a network meta-analysis

CONCLUSIONS: Based on moderate-certainty evidence, somatostatin analogues alone and vasopressin analogues alone (with supportive therapy) probably result in increased mortality, compared to endoscopic sclerotherapy. Based on moderate-certainty evidence, vasopressin analogues alone and band ligation alone probably result in fewer adverse events compared to endoscopic sclerotherapy. Based on low-certainty evidence, balloon tamponade plus sclerotherapy may result in large increases in serious adverse events compared to sclerotherapy. Based on low-certainty evidence, sclerotherapy plus somatostatin analogues may result in large decreases in symptomatic rebleed compared to sclerotherapy. In the remaining comparisons, the evidence indicates considerable uncertainty about the effects of the interventions, compared to sclerotherapy.PMID:33837526 | DOI:10.1002/14651858.CD013155.pub2

Source: Cochrane Database of Systematic Reviews - April 10, 2021 Category: General Medicine Authors: Danielle Roberts Lawrence Mj Best Suzanne C Freeman Alex J Sutton Nicola J Cooper Sivapatham Arunan Tanjia Begum Norman R Williams Dana Walshaw Elisabeth Jane Milne Maxine Tapp Mario Csenar Chavdar S Pavlov Brian R Davidson Emmanuel Tsochatzis Kurinchi Se Source Type: research