Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkin's lymphoma patients

Wien Klin Wochenschr. 2021 Apr 9. doi: 10.1007/s00508-021-01850-x. Online ahead of print.ABSTRACTWe retrospectively investigated clinical and prognostic significance of psoas muscle index (PMI) calculated as total psoas muscle area at L3 vertebra level obtained from baseline computed tomography (CT) scans in 49 newly diagnosed classical Hodgkin's lymphoma (cHL) patients prior to specific treatment. Median PMI was 572.5 mm2/m2 and was significantly higher in males (P < 0.001), patients with higher body mass index (BMI, P < 0.001), absence of extranodal disease (P = 0.037), higher absolute lymphocyte count (P = 0.037), higher hemoglobin (P = 0.010) and lower lactate dehydrogenase (LDH, P = 0.050). There were no significant associations with age, disease subtype, presence of constitutional symptoms, Ann Arbor disease stage, presence of advanced disease or international prognostic score. Patients with lower PMI had significantly worse PFS (hazard ratio [HR] 4.91; P = 0.009). This phenomenon persisted in the multivariate model (HR = 5.09; P = 0.042) adjusted for International Prognostic Score (IPS) and chemotherapy type.PMID:33835267 | DOI:10.1007/s00508-021-01850-x

Source: Wiener Klinische Wochenschrift - April 9, 2021 Category: General Medicine Authors: Marko Lucijani ć Renata Huzjan Koruni ć Marija Ivi ć Amina Fazli ć Džankić Željko Jonjić Zdravko Mitrovi ć Željko Prka Mario Pir šić Ozren Jak šić Petar Ga ćina Josipa Vlasac Glasnovi ć Vlatko Pej ša Source Type: research