Structure-function of anticoagulant TIX-5, the inhibitor of Factor Xa-mediated FV activation

CONCLUSION: The structure-function properties of TIX-5 are in perfect agreement with a protein that inhibits the FXa-mediated activation on a phospholipid surface. The present elucidation of the mechanism of action of TIX-5 will aid in deciphering the processes involved in the initiation phase of blood coagulation.PMID:33829620 | DOI:10.1111/jth.15329

Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Anja Maag Priyanka Sharma Tim J Schuijt Wil F Kopatz Dani ëlle Kruijswijk J Arnoud Marquart Tom van der Poll Tilman M Hackeng Gerry A F Nicolaes Joost C M Meijers Mettine H A Bos Cornelis van 't Veer Source Type: research