Sex-specific differences in clot resolution 3 weeks after acute pulmonary embolism managed with anticoagulants - a substudy of the Einstein-PE study

CONCLUSIONS: A total of 371 participants including 174 (46.9%) women and 197 (53.0%) men were included in the present analysis. At 3 weeks, there was no difference between men and women in complete clot resolution: 39.6% and 40.2%, respectively. The absolute reduction in pulmonary vascular obstruction at week 3 was also similar: 12.9% (95% CI: 11.6 to 14.2) in men and 12.1% (95% CI: 10.4 to 13.7) in women, corresponding to a resolution ratio of 0.29 (95% CI: 0.24 to 0.33) and 0.35 (95% CI: 0.28 to 0.42), respectively No differences in clot resolution were observed between men and women diagnosed with acute PE at 3 weeks after start of anticoagulant therapy. These findings suggest that the reported higher rate of VTE recurrence in men cannot be explained by decreased clot resolution.PMID:33829647 | DOI:10.1111/jth.15326

Source: Thrombosis and Haemostasis - April 8, 2021 Category: Hematology Authors: Hanke M G Wiegers Josien van Es Ákos F Pap Anthonie W A Lensing Saskia Middeldorp Luuk J J Scheres Source Type: research