Osteogenic differentiation factors of multipotent mesenchymal stromal cells in the current understanding

CONCLUSION: It is concluded that it is necessary to move from studies focused of the effects of local genes to those taking multiple measurements of the gene-regulatory profile and the biomolecules critical for the implementation of numerous, incompletely studied osteogenic factors of endogenous and exogenous origin. Among the cornerstones of future (epi)genetic studies, whether osteomodulatory effects are realized through specific signaling pathways and/or whether cross-signaling with known genes drives the osteogenic differentiation of MSCs remain to be determined.PMID:33823770 | DOI:10.2174/1381612827666210406150027
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Source Type: research