The prognostic impact of daytime and seasonality of radiotherapy on head and neck cancer

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common malignancy globally, and most of the patients require radiotherapy (RT) as part of a single- or multimodal treatment plan [1]. Despite advances in surgery, RT and systemic treatment [2 –5], the 5-year cumulative all-cause mortality is about 51% [6]. In treatment of HNSCC, RT is usually delivered in daily fractions over a course of 6 to 7 weeks. As a possible method to reduce RT-associated toxicities and increase tumor control, “chronoradiotherapy” was investigated by several research groups in the past.

Source: Radiotherapy and Oncology - April 9, 2021 Category: Radiology Authors: Olgun Elicin, Eliane Koller Brolese, Beat Bojaxhiu, Burim Sermaxhaj, Daniel Hendrik Schanne, Etienne Mathier, Jana Lippmann, Mohamed Shelan, Yannick Eller, Daniel Matthias Aebersold, Roland Giger, Nikola Cihoric Tags: Original Article Source Type: research