Structures of chromatin modulators in complex with nucleosome

Curr Opin Chem Biol. 2021 Apr 3;63:105-114. doi: 10.1016/j.cbpa.2021.02.018. Online ahead of print.ABSTRACTThe chromatin structure is dynamically regulated by many different modulators that post-translationally modify histones, replace canonical histones with histone variants, and unwind nucleosomal DNA, thereby modulating the accessibility of nucleosomal DNA and facilitating downstream DNA-templated nuclear processes. To understand how these modulators change the chromatin structure, it is essential to determine the 3D structures of chromatin modulators in complex with nucleosome. Here, we review the very recent progress in structural studies of some selected chromatin modulators in complex with nucleosome, including those of histone demethylases LSD1/2, some pioneer transcription factors, and the PWWP domain-containing protein LEDGF.PMID:33823458 | DOI:10.1016/j.cbpa.2021.02.018
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Source Type: research