Genetic Association of < em > PPARGC1A < /em > Gene Single Nucleotide Polymorphism with Milk Production Traits in Italian Mediterranean Buffalo

This study identified polymorphisms in the PPARGC1A gene in Italian Mediterranean buffaloes and their associations to milk production and quality traits (lactation length, peak milk yield, fat and protein yield, and percentage). As a result, a total of seven SNPs (g.-78A>G, g.224651G>C, g.286986G>A, g.304050G>A, g.325647G>A, g.325817T>C, and g.325997G>A) were identified by DNA pooled sequencing. Analysis of productivity traits within the genotyped animals revealed that the g.286986G>A located at intron 4 was associated with milk production traits, but the g.325817T>C had no association with milk production. Polymorphisms in g.-78A>G was associated with peak milk yield and milk yield, while g.304050G>A and g.325997 G>A were associated with both milk yield and protein percentage. Our findings suggest that polymorphisms in the buffalo PPARGC1A gene are associated with milk production traits and can be used as a candidate gene for milk traits and marker-assisted selection in the buffalo breeding program.PMID:33829059 | PMC:PMC8004361 | DOI:10.1155/2021/3653157

Source: Biomed Res - April 8, 2021 Category: Research Authors: Seyed Mahdi Hosseini Ye Tingzhu Majid Pasandideh Aixin Liang Guohua Hua None Farmanullah Nicola M Schreurs Sayed Haidar Abbas Raza Angela Salzano Giuseppe Campanile Bianca Gasparrini Liguo Yang Source Type: research