Subclinical infection can be an initiator of inflammaging leading to degenerative disk disease: evidence from host-defense response mechanisms

ConclusionsThe predominance of HDRPs involved in complement cascades, neutrophil degranulation, and oxidative-stress regulation indicated an ongoing infection mediated inflammatory process in DD. Our study has documented increasing evidence for bacteria ’s role in triggering the innate immune system leading to chronic inflammation and degenerative disk disease.
Source: European Spine Journal - Category: Orthopaedics Source Type: research