COVID-19 Patient Receives Lung Transplant From Living Donors

TOKYO — Doctors in Japan announced Thursday they have successfully performed the world’s first transplant of lung tissue from living donors to a patient with severe lung damage from COVID-19. The recipient, identified only as a woman from Japan’s western region of Kansai, is recovering after the nearly 11-hour operation on Wednesday, Kyoto University Hospital said in a statement. It said her husband and son, who donated parts of their lungs, are also in stable condition. The university said it was the world’s first transplant of lung tissue from living donors to a person with COVID-19 lung damage. Transplants from brain-dead donors in Japan are still rare, and living donors are considered a more realistic option for patients. “We demonstrated that we now have an option of lung transplants (from living donors),” Dr. Hiroshi Date, a thoracic surgeon at the hospital who led the operation, said at a news conference. “I think this is a treatment that gives hope for patients” with severe lung damage from COVID-19, he said. Kyoto University said dozens of transplants of parts of lungs taken from brain-dead donors to patients with COVID-19-related lung damage have been carried out in the United States, Europe and China. The woman contracted COVID-19 late last year and developed breathing difficulties that rapidly worsened. She was placed on a life support machine that works as an artificial lung for more than three months at another ho...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 overnight wire Source Type: news

Related Links:

ConclusionsOur study reveals unfavorable consequences of COVID-19 pandemic restrictions on PA of pwCF with unknown long-term consequences for their overall physical fitness and lung health. Strategies to overcome this undesirable situation are needed; increased uptake of telehealth PA programs and virtual exercise classes to promote PA participation might be one promising approach along with vaccination of pwCF and their close contacts.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Exp Clin Transplant. 2021 Sep 20. doi: 10.6002/ect.2021.0223. Online ahead of print.ABSTRACTIn the COVID-19 pandemic presently affecting the whole world, solid-organ transplant recipients under immunosuppressive therapy are at higher risk than the general population. COVID-19 infection primarily affects the lungs, and so the risk is further increased in lung transplant recipients. The course of COVID-19 in lung transplant recipients is unclear. Here, we present the intensive care follow-up and treatment process of a bilateral lung transplant recipient who developed acute respiratory failure due to COVID-19, for whom the fi...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Source Type: research
This special article focuses on the highlights in the cardiothoracic transplantation literature in the year 2020. Part I encompasses the recent literature on lung transplantation including the advances in preoperative assessment and optimization, donor management including the use of ex-vivo lung perfusion, recipient management including those who have been infected with COVID-19, updates on the perioperative management including the use of extracorporeal membrane oxygenation, and long-term outcomes.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Source Type: research
This article describes the experience of the National Lung Transplant Centre in Ireland in changing established care pathways for lung transplant recipients during the pandemic. The innovations which were put in place to protect this clinically vulnerable group are discussed. With the advancement of technology and remote monitoring systems available, patient-focused strategies and community-based interventions were implemented. Additional strategies have been implemented so that the new model of care can be safely maintained.PMID:34514821 | DOI:10.12968/bjon.2021.30.16.976
Source: British Journal of Nursing - Category: Nursing Authors: Source Type: research
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
On Sept. 7, the country’s leading COVID-19 doctor issued a dire warning about the growing number of pandemic cases in the country, and the shrinking number of ICU beds available to care for the sickest people. Speaking on CNN, Dr. Anthony Fauci, the chief White House medical advisor, said we are “perilously close in certain areas of the country of getting so close to having full occupancy that you’re going to be in a situation where you’re going to have to make some tough choices.” Those tough choices, he admitted, include discussions about whether scarce resources should go to people who have...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
We describe the case of a 30-year-old male kidney transplant recipient from Wuhan, China that was treated for severe COVID-19 in February 2020. He suffered an acute lung and renal injury and required systemic treatment including adjustment of his immunosuppressant regime. He was followed up to 1-year after discharge. No chronic lung fibrosis or deterioration of his pulmonary function was observed. Despite COVID-19 mediated damage to his renal tubular cells, no transplant rejection occurred. His immunological profile demonstrated both cellular anti-SARS-CoV-2 reactivity and specific humoral immunity, indicating that it is b...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Med Sci Monit. 2021 Sep 4;27:e932025. doi: 10.12659/MSM.932025.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic, due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in March 2020, affected organ donor acceptance and rates of heart, lung, kidney, and liver transplants worldwide. According to data reported to POLTRANSPLANT, the number of solid organ transplants decreased by over 35% and the number of patients enlisted de novo for organ transplantation was reduced to 70% of its pre-COVID-19 volume in Poland. Most transplant centers in Western Europe and the USA have also dra...
Source: Medical Science Monitor - Category: Research Authors: Source Type: research
ConclusionsWe suggest that a lung transplantation may be a viable treatment for patients with end-stage pulmonary failure secondary to COVID-19 in selected situations.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
The repeated waves of the COVID-19 pandemic have highlighted the necessity to optimize vaccine responses in immunocompromised populations. We investigated the safety and immunogenicity of a third, booster, dose of the Pfizer BNT162b2 vaccine in heart transplant (HT) patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
More News: Brain | Cardiovascular & Thoracic Surgery | China Health | Conferences | COVID-19 | Health | Hospitals | Japan Health | Lung Transplant | Neurology | Transplant Surgery | Transplants | USA Health