The Clinical Impact of Proteomics in Amyloid Typing

Systemic amyloidosis, a serious and often life-threatening disease, is characterized by extracellular deposition of abnormal protein aggregates in blood-vessel walls and tissues, often leading to organ failure. Presenting symptoms are frequently vague, and pathognomonic findings are uncommon, which can result in a delay in diagnosis. However, once the possibility of amyloidosis is raised, the diagnosis can usually be established by tissue biopsy. Typically, biopsy is performed on a clinically involved organ, although sometimes tissue from a more easily accessible site, such as fat pad or bone-marrow biopsy, is sufficient.

Source: Mayo Clinic Proceedings - April 8, 2021 Category: Internal Medicine Authors: Michelle M. Hill, Surendra Dasari, Peter Mollee, Giampaolo Merlini, Catherine E. Costello, Bouke P.C. Hazenberg, Martha Grogan, Angela Dispenzieri, Morie A. Gertz, Taxiarchis Kourelis, Ellen D. McPhail Tags: Commentary Source Type: research