Development and validation of a normal tissue complication probability model for acquired nasal cavity stenosis and atresia after radical radiotherapy for nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is an endemic malignancy in East and South-East Asia. With the widespread application of intensity-modulated radiotherapy (IMRT) and optimization of chemotherapy regimens, the mortality rate of patients with NPC has been reduced substantially. According to previous studies, the 5-year overall survival rates for patients with stage I-IV NPC were 100%, 91%, 72%, and 44% respectively, meaning NPC has become a highly curable disease [1 –4]. However, the quality of life in survivors is often highly impaired because of toxicity associated with comprehensive radical treatment [5,6].

Source: Radiotherapy and Oncology - April 8, 2021 Category: Radiology Authors: Jin-Jie Yan, Shan-Shan Guo, Da-Feng Lin, Li-Ting Liu, Sai-Lan Liu, Bei-Bei Xiao, Jin-Hao Yang, Dong-Xiang Wen, Zhen-Chong Yang, Yu-Jing Liang, Qing-Nan Tang, Chao Lin, Xiao-Yun Li, Xue-Song Sun, Ji-Bin Li, Lin-Quan Tang, Qiu-Yan Chen, Hai-Qiang Mai Tags: Original Article Source Type: research