Co-production of Tet(X7) conferring high-level tigecycline resistance, fosfomycin FosA4 and colistin Mcr-1.1 in < em > Escherichia coli < /em > strains from chickens in Egypt

Antimicrob Agents Chemother. 2021 Apr 5:AAC.02084-20. doi: 10.1128/AAC.02084-20. Online ahead of print.ABSTRACTThe plasmid-mediated tet(X7) conferring high-level tigecycline resistance was identified in five mcr-1.1-positive Escherichia coli strains [ST10 (n=3), and ST155 (n=2)] isolated from chickens, Egypt. Two fosfomycin-resistant fosA4-carrying IncFII plasmids (⁓79 kb in size) were detected. Transposase ISCR3 (IS91 family) is syntenic with tet(X7) in all isolates suggesting its role in the mobilization of tet(X7). To our knowledge, this is the first global report of (ST4)-IncHI2 plasmids co-carrying tet(X7) and mcr-1.1 from chickens.PMID:33820767 | DOI:10.1128/AAC.02084-20

Source: Antimicrobial Agents and Chemotherapy - April 6, 2021 Category: Microbiology Authors: Ahmed M Soliman Hazem Ramadan Hoda Zarad Yo Sugawara Liansheng Yu Motoyuki Sugai Toshi Shimamoto Lari M Hiott Jonathan G Frye Charlene R Jackson Tadashi Shimamoto Source Type: research