The impact of physical exercise on hippocampus, in physiological condition and ageing-related decline: current evidence from animal and human studies

Curr Pharm Biotechnol. 2021 Apr 5. doi: 10.2174/1389201022666210405142611. Online ahead of print.ABSTRACTPhysical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results to be a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various districts of the body, determining biological and psychological benefits. Additionally, in elderly, PE might represent a remarkable tool reducing cognitive impairments related to the normal aging processes and it has also been found to have an impact in neurodegenerative diseases such as Alzheimer's disease. The present review aims to provide an overview about PE effects on hippocampus, since it is one of the brain regions most susceptible to aging and, therefore, involved in diseases characterized by cognitive impairment.PMID:33820516 | DOI:10.2174/1389201022666210405142611
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Source Type: research