Brain hypometabolic changes in 14 adolescent –adult patients with Niemann–Pick disease type C assessed by 18F-fluorodeoxyglucose positron emission tomography

ConclusionsWe found bilateral symmetric hypometabolism of the frontal lobes, thalami and parietal lobes (especially posterior cingulate gyrus) to be typical of adolescent –adult NPC. Ataxia was commonly associated with cerebellar or thalamic hypometabolism. Frontal lobe hypometabolism showed the best inverse correlation with clinical severity.
Source: Journal of Neurology - Category: Neurology Source Type: research