Adjunctive vitamin A and D for glycemic control in patients with concurrent type 2 diabetes and tuberculosis: a randomized controlled trial

The objective of this study is to investigate the effects of vitamin A, D and their interaction on the glycemic control in patients with both diabetes and tuberculosis. Tuberculosis infection and its treatment induce hyperglycemia and complicate the glycemic control in patients with diabetes. A randomized controlled trial with a 2×2 factorial design was conducted in a tuberculosis-specialized hospital in Qingdao, China. A total of 279 patients who have both diabetes and tuberculosis were included in this analysis. The patients received standard anti-tuberculosis treatment alone (control group), or together with a dose of vitamin A (2,000 IU/d), or vitamin D (400 IU/d) or a combination of vitamin A (2,000 IU/d) and vitamin D (400 IU/d) for two months. The effects of the intervention on fasting plasma glucose and 2 h postprandial blood glucose were investigated by analysis of covariance. The analysis was adjusted for baseline values, age, sex, smoking, drinking and antidiabetic treatment as covariates. No significant effect was observed for vitamin A and D supplementation on fasting plasma glucose, 2 h postprandial blood glucose, BMI and related blood parameters. No interaction was observed between vitamin A and D supplementation for these endpoints. Vitamin A and D supplementation showed a null effect on the glycemic control for patients with concurrent diabetes and tuberculosis. Future work should evaluate the effect of vitamin A and D supplementation on insulin-related indi...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Source Type: research