Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta-analysis

CONCLUSIONS: Based on low-certainty evidence, beta-blockers, variceal band ligation, sclerotherapy, and beta-blockers plus nitrates may decrease mortality compared to no intervention in people with high-risk oesophageal varices in people with cirrhosis and no previous history of bleeding. Based on low-certainty evidence, variceal band ligation may result in a higher number of serious adverse events than beta-blockers. The evidence indicates considerable uncertainty about the effect of beta-blockers versus variceal band ligation on variceal bleeding. The evidence also indicates considerable uncertainty about the effect of the interventions in most of the remaining comparisons.PMID:33822357 | DOI:10.1002/14651858.CD013121.pub2

Source: Cochrane Database of Systematic Reviews - April 6, 2021 Category: General Medicine Authors: Davide Roccarina Lawrence Mj Best Suzanne C Freeman Danielle Roberts Nicola J Cooper Alex J Sutton Amine Benmassaoud Maria Corina Plaz Torres Laura Iogna Prat Mario Csenar Sivapatham Arunan Tanjia Begum Elisabeth Jane Milne Maxine Tapp Chavdar S Pavlov Br Source Type: research