Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases

Calcium (Ca2+) is a second messenger essential for cellular homeostasis. Inside the cell, Ca2+ is compartmentalized and exchanged among organelles in response to both external and internal stimuli. Mitochondria ‐associated membranes (MAMs) provide a platform for proteins and channels involved in Ca2+ transfer between the endoplasmic reticulum (ER) and mitochondria. Deregulated Ca2+ signaling and proteins regulating ER –mitochondria interactions have been linked to liver diseases and intensively investigated in recent years. In this review, we summarize the role of MAM‐resident proteins in Ca2+ transfer and their association with different liver diseases.
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Review Article Source Type: research