Claudin-1 down-regulation in the prostate is associated with aging and increased infiltration of inflammatory cells in BPH

CONCLUSIONS: These findings suggest that aging is associated with down-regulation of claudin-1 and claudin-1 is further decreased in BPH. Claudin-1 down-regulation was associated with increased infiltration of inflammatory cells in both NAP and BPH tissues. Claudin-1 down-regulation in the aging prostate could contribute to increased prostatic inflammation, subsequently contributing to BPH pathogenesis.PMID:33816694 | PMC:PMC8012836

Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Laura E Pascal Rajiv Dhir Goundappa K Balasubramani Wei Chen Chandler N Hudson Pooja Srivastava Anthony Green Donald B DeFranco Naoki Yoshimura Zhou Wang Source Type: research