Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-blind Study With Long-term Extension

Pediatric functional constipation (PFC) is a common problem in children that causes distress and presents treatment challenges to healthcare professionals. We conducted a randomized, placebo-controlled trial (Study 1) in patients with PFC (aged 6-17 years) to evaluate the efficacy and safety of lubiprostone, followed by an open-label extension for those who completed the placebo-controlled phase (Study 2).

Source: Clinical Gastroenterology and Hepatology - April 6, 2021 Category: Gastroenterology Authors: Marc A. Benninga, Sunny Z. Hussain, Manu R. Sood, Samuel Nurko, Paul Hyman, Robert A. Clifford, Molly O ’Gorman, Taryn Losch-Beridon, Shadreck Mareya, Peter Lichtlen, Carlo Di Lorenzo Source Type: research