Pharmacokinetics and Safety of Lefamulin After Single Intravenous Dose Administration in Subjects with Impaired Hepatic Function

ConclusionLefamulin was generally well tolerated. Differences in lefamulin and BC ‐8041 pharmacokinetics were small, relative to the overall variability, and any changes appear to be compensated by increases in renal clearance and decreased protein binding.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 3, 2021 Category: Drugs & Pharmacology Authors: Wolfgang W. Wicha, Thomas C. Marbury, James A. Dowell, Jared L. Crandon, Cathie Leister, James Ermer, Steven P. Gelone Tags: EXPERIMENTAL THERAPEUTICS Source Type: research