BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis

CONCLUSION: Our data support a "BRUCE-PKA-β-catenin" signaling axis in the mouse liver. The BRUCE interaction with PKA in hepatocytes suppresses PKA-dependent phosphorylation and activation of β-catenin. This study implicates BRUCE as a novel negative regulator of both PKA and β-catenin in chronic liver disease progression. Furthermore, BRUCE-liver specific KO mice serve as a promising model for understanding hepatic fibrosis and HCC in patients with aberrant activation of PKA and β-catenin.PMID:33815677 | PMC:PMC8006081 | DOI:10.4254/wjh.v13.i3.343

Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Chrystelle L Vilfranc Li-Xiao Che Krushna C Patra Liang Niu Olugbenga Olowokure Jiang Wang Shimul A Shah Chun-Ying Du Source Type: research