Influence of strain, age, origin, and anesthesia on the cardioprotective efficacy by local and remote ischemic conditioning in an ex vivo rat model

ConclusionThe cardioprotective effect of IPC is consistent across rat strains independent of age, strain, and supplier. RIC seems to be less reproducible, but still yields protection across different rat strains. However, age, animal supplier, and anesthetics may modulate the sensitivity of IR ‐injury and the response to RIC.

https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.14810?af=R

Source: Physiological Reports - April 5, 2021 Category: Physiology Authors: Thomas Ravn Lassen, Marie Vognstoft Hjortbak, Marie Hauerslev, Pernille Tilma Tonnesen, Steen Buus Kristiansen, Rebekka Vibjerg Jensen, Hans Erik B øtker Tags: ORIGINAL ARTICLE Source Type: research