LSU Health New Orleans study discovers source of Zika neurodevelopmental defects

(Louisiana State University Health Sciences Center) A study led by Edward Wojcik, PhD, Associate Professor of Biochemistry&Molecular Biology at LSU Health New Orleans School of Medicine, identified how microcephaly (abnormally small heads) and blindness may develop in Zika-infected fetuses, as well as a new way to potentially prevent these neurodevelopmental defects.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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To the Editor We read with interest the article by Zeng et al that reported on 33 neonates of women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy, where 3 of 33 had early-onset SARS-CoV-2 infection. The 3 affected neonates were born 1 to 3 days after their mothers were diagnosed as having SARS-CoV-2, developed symptoms within the first 2 days of life, and had positive SARS-CoV-2 polymerase chain reaction from nasopharyngeal and anal samples on days 2 and 4 of life. It is unclear whether these infants were infected intrauterine or after birth, especially because it is not yet kn...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
Discussion According to the World Health Organization, about 1.3 billion people have some form of visual impairment. Most people with visual impairments are>50 years old, more are female than male, and more live in resource-limited areas than resource-rich areas. Most visual impairments are avoidable (80%) in all age groups with the leading causes globally and across ages being uncorrected refractive errors and cataracts. The most common causes of blindness are: Refractive errors, uncorrected Cataract Age-related macular degeneration Glaucoma Diabetic retinopathy Corneal opacity Trachoma The exact numbers vary by regi...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Prevent Blindness. 10/18/2017 This one-hour webinar discusses the Zika virus, and how it affects vision in babies whose mothers were infected with the virus during pregnancy and in infants diagnosed with congenital Zika syndrome. It provides information about how professionals working with expectant mothers and parents of babies with congenital Zika syndrome can provide direct support and increase access to supportive services for vision impairment and low vision services. (Video or Multimedia)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Authors: Source Type: news
ABSTRACT Charles Miller Fisher is considered the father of modern vascular neurology and one of the giants of neurology in the 20th century. This historical review emphasizes Prof. Fisher's magnificent contribution to vascular neurology and celebrates the 65th anniversary of the publication of his groundbreaking study, “ Transient Monocular Blindness Associated with Hemiplegia. ”RESUMO Charles Miller Fisher é considerado o pai da neurologia vascular moderna, e um dos gigantes da neurologia no século XX. Esta revisão histórica enfatiza a magnífica contribuição de ...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Publication date: December 2017 Source:Current Opinion in Virology, Volume 27 Author(s): Derek J Platt, Jonathan J Miner The 2015 Zika virus (ZIKV) epidemic in the Americas led to the discovery that ZIKV causes congenital abnormalities including microcephaly, intrauterine growth restriction, and eye disease that can result in blindness. Studies in animal models and human organoid cultures, together with human epidemiological studies, have shown that ZIKV crosses the placenta and subsequently replicates within fetal tissues including the developing brain. Preferential infection of neural cell precursors causes damage to th...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Impairments range in severity, two studies foundSource: HealthDay Related MedlinePlus Pages: Infections and Pregnancy, Vision Impairment and Blindness, Zika Virus
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news
(Elsevier) There is a broad collection of anomalies now known as congenital Zika syndrome (CZS). Some of the most serious are ophthalmologic. Two papers published in the Journal of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) evaluated visual function among infants with suspected and confirmed CZS. Both studies found that while about 40 percent of patients had ocular abnormalities, 100 percent of children tested had visual impairment. Thus, cortical visual impairment might be the most common cause of blindness among children with CZS.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
All infants with prenatal exposure to the virus need a vision exam, researchers saySource: HealthDay Related MedlinePlus Pages: Fetal Health and Development, Vision Impairment and Blindness, Zika Virus
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news
Although it differs in important details, the draft Medicaid provisions of the Better Care Reconciliation Act — the Senate’s version of Affordable Care Act “repeal and replace” —  share the vision of its House-passed counterpart, the American Health Care Act: to, as much as possible, shield the federal government from the cost of Medicaid. Like the House, the Senate would accomplish this goal by fundamentally altering the terms of Medicaid itself rather than by ending it and replacing its entitlement structure with a new, successor program as Congress did in 1996 when it replaced the Aid ...
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Featured Following the ACA Medicaid and CHIP Uncategorized ACA repeal and replace block grants Medicaid per capita cap Trumpcare Source Type: blogs
Conclusions Children with CZS demonstrated visual impairment regardless of retina and/or optic nerve abnormalities. This finding suggests that cerebral visual impairment may be the most common cause of blindness identified in children with CZS.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
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